反应详情

温度

150 °C

622 g (4.5 mol) of isophorone and 1.8 g (12.9 mmol) of 1,3-dimethylimidazolium-4-carboxylate were placed in a reaction vessel and a mixture of 207.3 g (1.5 mol) of isophorone and 81.0 g (3 mol) of hydrogen cyanide was added at 150° C. over a period of about 60 minutes. The mixture was subsequently stirred further for about 60 minutes at 150° C. After cooling, the HCN concentration was determined by titration. No free hydrocyanic acid could be detected (HCN conversion>99.9%). After addition of 2.0 g of 85% strength H3PO4, the reaction product was distilled at 0.1 hPa. This gave 486 g of 3-cyano-3,5,5-trimethylcyclohexanone (98.1% based on HCN used). The amount of distillation residue was only 3% by weight, based on isophorone used.

1. additionwas added at 150° C. over a period of about 60 minutes
2. temperatureAfter cooling
3. concentrationthe HCN concentration
4. additionAfter addition of 2.0 g of 85% strength H3PO4
5. distillationthe reaction product was distilled at 0.1 hPa
6. distillationThe amount of distillation residue