4-Methylanisole → 4-Methoxybenzaldehyde

HRID 377097Notes

Reaction equation

HRID 377097 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[OH:10]N1C2C=CC=CC=2N=N1>>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([CH:1]=[O:10])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 77314-MethylanisoleHCID 757711-Hydroxybenzotriazole

Product 1

HCID 312444-MethoxybenzaldehydeYield 48%

Procedure

195 mg (1.60 mmol) of 4-methylanisole were reacted analogously to Example 1 in the presence of 24.3 mg (0.180 mmol) of 1-hydroxy-1H-benzotriazole. After a reaction time of 22 hours, the reaction solution was extracted with chloroform and examined by NMR spectroscopy. Yield 48% of 4-methoxybenzaldehyde (approx. 90%, based on conversion).

Workup

  1. extractionAfter a reaction time of 22 hours, the reaction solution was extracted with chloroform

Sources & evidence

ORD record
ord-5ad7d131b2ac43b78c65488211d056a0
Source dataset
uspto-grants-2000_02
Patent number
US06023000

Reaction notes

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