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HRID377119

反应详情

EQUATION

反应方程式

HRID 377119 的结构方程式

REACTANTS

反应物

3
结构：N
HCID222

Ammonia gas

H3N

结构：O=C1CSC(=O)N1
HCID5437

Thiazolidinedione

C3H3NO2S

结构：CCc1ccc(CCOc2ccc(C=O)cc2)nc1
HCID9881522

4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzaldehyde

C16H17NO2

PRODUCTS

生成物

1
结构：CCc1ccc(CCOc2ccc(C=C3SC(=O)NC3=O)cc2)nc1
HCID53394892

5-({4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl}methylidene)-4-hydroxy-1,3-thiazol-2(5H)-one

C19H18N2O3S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 4-[2-(5-ethyl-2-pyridyl)ethoxy]benzaldehyde (27 g), ethanol (300 ml), 2,4-thiazolidinedione (33 g) and concentrated aqueous ammonia (14 ml) was heated under reflux for 5 hours. The precipitated crystals were separated. Recrystallization from 1,2-dichloroethane gave 21.6 g (57.6% of crystals of 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzylidene}-2,4-thiazolidinedione.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. customThe precipitated crystals were separated
  4. customRecrystallization from 1,2-dichloroethane