HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Benzaldehyde, 4-[2-(5-ethyl-2-pyridinyl)ethoxy]- | HCID 9881522 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione | HCID 53394892 | — |
Reaction Steps
A mixture of 4-[2-(5-ethyl-2-pyridyl)ethoxy]benzaldehyde (27 g), ethanol (300 ml), 2,4-thiazolidinedione (33 g) and concentrated aqueous ammonia (14 ml) was heated under reflux for 5 hours. The precipitated crystals were separated. Recrystallization from 1,2-dichloroethane gave 21.6 g (57.6% of crystals of 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzylidene}-2,4-thiazolidinedione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE036575 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-465f2299222b49309eb3c4b176997399 |
| Source note | uspto-grants-2000_02 |