HCID 54162563, compound → HCID 19358290, compound

HRID 377199Notes

Reaction equation

HRID 377199 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]1[CH2:17][CH2:18][N:19]1[CH2:28][CH2:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20]1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]1[CH2:17][CH2:18][N:19]1[CH2:28][CH2:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20]1

Participants

4

Reactant 1

HCID 54162563HCID 54162563, compound

Product 1

HCID 19358290HCID 19358290, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 23938PalladiumSolvent

Procedure

The protected amine 2-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]piperidine-1-carboxylic acid benzyl ester (D3, 14 g, 0.037 mol) was dissolved in ethanol (300 ml) and hydrogenated over 10% Pd/C for 18 hours to afford the title compound (9 g, 100%). MH+ 245.

Sources & evidence

ORD record
ord-e06f9d5b5e1d42e88bfac27810c5ca53
Source dataset
uspto-grants-2000_02
Patent number
US06025367

Reaction notes

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