反应详情

温度

0 °C

33.5 g (0.3 mol) of potassium tert-butylate are initially introduced into 100 ml of anhydrous DMF at 0° C., and 51.6 g (0.25 mol) of tert-butyl 4methylphenyl-acetate in 250 ml of anhydrous DMF are added dropwise. The mixture is stirred at 0° C. for 30 minutes, 32.2 ml (0.3 mol) of cyclopentyl bromide in 150 ml of anhydrous DMF are added dropwise at 5-15° C. and the mixture is stirred at 25° C. for 20 hours. After concentration, the residue is partitioned between water and diethyl ether and the ether phase is dried over sodium sulphate and concentrated. The product crystallizes out.

1. stirringthe mixture is stirred at 25° C. for 20 hours
2. concentrationAfter concentration
3. customthe residue is partitioned between water and diethyl ether
4. dry with materialthe ether phase is dried over sodium sulphate
5. concentrationconcentrated
6. customThe product crystallizes out