Water → HCID 15458198, compound

HRID 377278Notes

Reaction equation

HRID 377278 reaction equation
[Br:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:8](=[CH:14][NH:15][CH:16]2[CH2:18][CH2:17]2)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:7])=[C:4](F)[C:3]=1[CH3:22].C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[Br:1][C:2]1[C:3]([CH3:22])=[C:4]2[C:5]([C:6](=[O:7])[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:14][N:15]2[CH:16]2[CH2:18][CH2:17]2)=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 178471853HCID 178471853, compound

Product 1

HCID 15458198HCID 15458198, compoundYield 96.9%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In 7 ml of dimethyl sulfoxide was dissolved 0.72 g of ethyl 2-(4-bromo-2-fluoro-3-methylbenzoyl)-3-cyclopropylaminoacrylate, followed by adding thereto 0.48 g of potassium carbonate, and the resulting mixture was stirred at 90° C. for 30 minutes. The reaction mixture was cooled to room temperature, after which 35 ml of water was added thereto and the crystals were collected by filtration to obtain 0.66 g of colorless ethyl 7-bromo-1-cyclopropyl-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate.

Workup

  1. additionby adding
  2. filtrationthe crystals were collected by filtration

Sources & evidence

ORD record
ord-9d8a57cb6c6248f3a25c86c0ee7d2ba8
Source dataset
uspto-grants-2000_02
Patent number
US06025370

Reaction notes

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