Ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]-1-cyclopenten-1-yl]phenoxy]acetate → Ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]cyclopentyl]phenoxy]acetate

HRID 377334Notes

Reaction equation

HRID 377334 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][C:19]3[CH2:23][CH2:22][CH2:21][C:20]=3[C:24]3[CH:25]=[C:26]([CH:34]=[CH:35][CH:36]=3)[O:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[Pd]>[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH:19]3[CH2:23][CH2:22][CH2:21][CH:20]3[C:24]3[CH:25]=[C:26]([CH:34]=[CH:35][CH:36]=3)[O:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[O:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 54404203Ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]-1-cyclopenten-1-yl]phenoxy]acetate

Product 1

HCID 53672804Ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]cyclopentyl]phenoxy]acetateYield 79.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]-1-cyclopenten-1-yl]phenoxy]acetate (0.5 g) in ethanol (20 ml) was added 10% palladium on carbon (100 mg). After being stirred for 6 hours under hydrogen atmosphere, the reaction mixture was filtered. The solvent was evaporated in vacuo to give ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]cyclopentyl]phenoxy]acetate (400 mg).

Workup

  1. filtrationthe reaction mixture was filtered
  2. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-3293a34090c84f3ba6e0a643fba58491
Source dataset
uspto-grants-2000_02
Patent number
US06025375

Reaction notes

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