HCID 86755140, compound → Ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]-2-hydroxycyclopentyl]phenoxy]-acetate

HRID 377335Notes

Reaction equation

HRID 377335 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][C:19]34[O:24][C:20]3([C:25]3[CH:26]=[C:27]([CH:35]=[CH:36][CH:37]=3)[O:28][CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:21][CH2:22][CH2:23]4)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[Pd]>[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][C:19]3([OH:24])[CH2:23][CH2:22][CH2:21][CH:20]3[C:25]3[CH:26]=[C:27]([CH:35]=[CH:36][CH:37]=3)[O:28][CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 86755140HCID 86755140, compound

Product 1

HCID 86755141Ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]-2-hydroxycyclopentyl]phenoxy]-acetateYield 51.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]-1,2-epoxycyclopentyl]phenoxy]acetate (500 mg) in ethanol (20 ml) was added palladium on carbon (0.5 g). After being stirred for 24 hours under hydrogen atmosphere, the reaction mixture was filtered. The solvent was evaporated in vacuo to give ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]-2-hydroxycyclopentyl]phenoxy]-acetate (260 mg).

Workup

  1. filtrationthe reaction mixture was filtered
  2. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-a338e07cd94d4b6bb4538b8ecd013b19
Source dataset
uspto-grants-2000_02
Patent number
US06025375

Reaction notes

Loading…