Diethyl Ether → HCID 44399137, compound

HRID 377337Notes

Reaction equation

HRID 377337 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([C:18]3[C@H:19]([CH2:23][C:24]4[CH:25]=[C:26]([CH:33]=[CH:34][CH:35]=4)[O:27][CH2:28][C:29]([O:31]C)=[O:30])[CH2:20][CH2:21][CH:22]=3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:37].CCOCC>C(O)C>[C:1]1([C:7]2[N:8]=[C:9]([C:18]3[C@H:19]([CH2:23][C:24]4[CH:25]=[C:26]([CH:33]=[CH:34][CH:35]=4)[O:27][CH2:28][C:29]([O-:31])=[O:30])[CH2:20][CH2:21][CH:22]=3)[O:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[Na+:37]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 14798Sodium HydroxideHCID 86755139HCID 86755139, compound

Product 1

HCID 44399137HCID 44399137, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (+)-methyl [3-[[(1S)-2-(4,5-diphenyloxazol-2-yl)-2-cyclopenten-1-yl]methyl]phenoxy]acetate (1.92 g) in ethanol (30 ml) was added 1N-aqueous sodium hydroxide (4.1 ml). The reaction mixture was stirred for 1 hour at room temperature. Ether (50 ml) was added to the solution. The precipitated solid was collected by filtration to afford (+)-sodium [3-[[(1S)-2-(4,5-diphenyloxazol-2-yl)-2-cyclopenten-1-yl]methyl]phenoxy]acetate (0.83 g).

Workup

  1. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-0a54bc4df4c44326a141ff2a89b8950a
Source dataset
uspto-grants-2000_02
Patent number
US06025375

Reaction notes

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