4-(4-Iodo-phenoxy)-benzenesulfonyl chloride → {[4-(4-Iodo-phenoxy)-benzenesulphonyl]-tert-butoxycarbonylmethyl-amino}-aceticacid tert-butyl ester

Participants

Reaction Steps

Compound 4e was prepared following the procedure described for 4a with reagent quantities adapted to the amount of starting material 3e (0.71 g, 1.81 mmol). Yield: 1.04 g, 1.64 mmol, 99% (white solid). 1H-NMR (DMSO-d6): δ 7.96 (d, 3J=8.5 Hz, 2H, ArH), 7.59 (d, 3J=8.5 Hz, 2H, ArH), 4.07 (s, 4H, 2×CH2CO2H), 1.40 (s, 18H, 2×CO2tBu).

Provenance & Evidence