Imidazole → HCID 19358829, compound

HRID 377502Notes

Reaction equation

HRID 377502 reaction equation
[CH2:1]([C:3]1[C:12]2[NH:11][C:10](=[O:13])[C:9]3=[CH:14][N:15]=[C:16]([CH2:17][CH3:18])[N:8]3[C:7]=2[N:6]=[C:5]([N:19]2[CH:23]=[CH:22][N:21]=[C:20]2CC)[N:4]=1)[CH3:2].N1C=CN=C1>CO>[CH2:1]([C:3]1[C:12]2[NH:11][C:10](=[O:13])[C:9]3=[CH:14][N:15]=[C:16]([CH2:17][CH3:18])[N:8]3[C:7]=2[N:6]=[C:5]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 19358835HCID 19358835, compound

Product 1

HCID 19358829HCID 19358829, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
-100 °C

Procedure

4,9-Diethyl-2-(2-ethyl-1H-imidazol-1-yl)imidazo[5,1-h]pteridin-6(5H)-one (5.0 g, 15 mmol) is heated with 50 g of imidazole at 200° C. under N2 for 16 hours. The reaction mixture is cooled to -100° C. and 150 mL of methanol is added. The solids are filtered and washed with methanol to provide 4,9-diethyl-2-(1H-imidazol-1-yl)imidazo[5,1-h]pteridin-6(5H)-one.

Workup

  1. filtrationThe solids are filtered
  2. washwashed with methanol

Sources & evidence

ORD record
ord-288afe3da129412392be65d4d62b7cc0
Source dataset
uspto-grants-2000_02
Patent number
US06025489

Reaction notes

Loading…