HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexene → 9-Ethyl-4-[(1-methylpiperidin-4-yl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexene | HCID 8079 | — |
| Reactant | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| Reactant | 2-Ethylimidazole | HCID 66130 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 1-Methyl-4-(methylamino)piperidine | HCID 566323 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 9-Ethyl-4-[(1-methylpiperidin-4-yl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one | HCID 70270934 | — |
Reaction Steps
Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with 1-methyl-4-(methylamino)piperidine followed by reaction with 2-ethylimidazole, reduction with palladium on carbon and cyclohexene in refluxing ethanol, and cyclization with carbonyidiimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06025489 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-3212f7b590b4430483b6c6024c3e6bfd |
| Source note | uspto-grants-2000_02 |