Ethanol → HCID 19358868, compound

HRID 377512Notes

Reaction equation

HRID 377512 reaction equation
[CH2:1]([C:3]1[N:15]2[C:6]([C:7](=[O:25])[NH:8][C:9]3[C:10]([N:16](CC4C=CC=CC=4)[CH3:17])=[N:11][CH:12]=[N:13][C:14]=32)=[CH:5][N:4]=1)[CH3:2].C(O)C.[OH-].[Na+]>[Pd]>[CH2:1]([C:3]1[N:15]2[C:6]([C:7](=[O:25])[NH:8][C:9]3[C:10]([NH:16][CH3:17])=[N:11][CH:12]=[N:13][C:14]=32)=[CH:5][N:4]=1)[CH3:2]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 19358862HCID 19358862, compound

Product 1

HCID 19358868HCID 19358868, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared by hydrogenation of the product of Example 19 with palladium on carbon in ethanol containing 2 eq. NaOH, at 50 psi and 50° C. for 24 hours. The catalyst was removed and the product was precipitated by addition of a saturated solution of ammonium chloride. The solids were filtered and washed with water and ethanol to provide 9-ethyl-4-(methylamino)imidazo[5,1-h]pteridin-6(5H)-one.

Workup

  1. customThe catalyst was removed
  2. customthe product was precipitated by addition of a saturated solution of ammonium chloride
  3. filtrationThe solids were filtered
  4. washwashed with water and ethanol

Sources & evidence

ORD record
ord-72de3ea056b249ccb286e2b325c6def6
Source dataset
uspto-grants-2000_02
Patent number
US06025489

Reaction notes

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