Dimethylamine → HCID 19358839, compound

HRID 377518Notes

Reaction equation

HRID 377518 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[CH3:12][NH:13][CH3:14].[CH2:15]([C:17]1[NH:18][CH:19]=[C:20]([CH3:22])[N:21]=1)[CH3:16].[Sn](Cl)Cl.[C:26](N1C=CN=C1)(N1C=CN=C1)=[O:27]>>[CH2:15]([C:17]1[N:18]2[C:19]([C:26](=[O:27])[NH:8][C:7]3[C:2]([N:13]([CH3:14])[CH3:12])=[N:3][CH:4]=[N:5][C:6]=32)=[C:20]([CH3:22])[N:21]=1)[CH3:16]

Participants

6

Reactant 5

HCID 674DimethylamineHCID 203124,6-Dichloro-5-nitropyrimidineHCID 24479Stannous ChlorideHCID 682631,1'-CarbonyldiimidazoleHCID 178437635HCID 178437635, compound

Product 1

HCID 19358839HCID 19358839, compound

Procedure

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with dimethylamine, followed by reaction with 2-ethyl-4-methylimidazole, reduction with tin (II) chloride, and cyclization with carbonyidiimidazole.

Sources & evidence

ORD record
ord-8eb66a6e91594998b0394c0b8e9cc121
Source dataset
uspto-grants-2000_02
Patent number
US06025489

Reaction notes

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