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HRID377522

反应详情

EQUATION

反应方程式

HRID 377522 的结构方程式

REACTANTS

反应物

7
结构：CCO
HCID702

Ethanol

C2H6O

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：O=[N+]([O-])c1c(Cl)ncnc1Cl
HCID20312

4,6-Dichloro-5-nitropyrimidine

C4HCl2N3O2

结构：[Cl][Sn][Cl]
HCID24479

未命名化合物

结构：c1ccc(CCNCc2ccccc2)cc1
HCID65055

N-Benzyl-1-phenethylamine

C15H17N

结构：O=C(n1ccnc1)n1ccnc1
HCID68263

1,1'-Carbonylbis(1H-imidazole)

C7H6N4O

结构：c1cn(Cc2ncc[nH]2)cn1
HCID19358846

2-(1H-Imidazol-1-ylmethyl)-1H-imidazole

C7H8N4

PRODUCTS

生成物

1
结构：O=c1[nH]c2c(NCCc3ccccc3)ncnc2n2c(Cn3ccnc3)ncc12
HCID9908192

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Pd]
催化剂HCID23938

Palladium

Pd

PROCEDURE

实验过程

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N-benzylphenethylamine, followed by reaction with 2-((1H-imidazol-1-yl)methyl)imidazole, reduction with tin (II) chloride, cyclization with carbonyidiimidazole and hydrogenation with palladium on carbon in ethanol containing 1.1 eq. NaOH at 50° C. and 50 psi.

WORKUP

后处理

  1. customat 50° C.