Sodium hydrosulfide → HCID 178508658, compound

HRID 377580Notes

Reaction equation

HRID 377580 reaction equation
Br[C:2]1[N:3]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4]2[C:9]([N:10]=1)=[C:8]([NH2:11])[N:7]=[CH:6][N:5]=2.[SH-:19].[Na+]>C(O)C>[CH2:12]([N:3]1[C:2]([SH:19])=[N:10][C:9]2[C:4]1=[N:5][CH:6]=[N:7][C:8]=2[NH2:11])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 28015Sodium hydrosulfideHCID 99045519-Benzyl-8-bromoadenine

Product 1

HCID 178508658HCID 178508658, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 8-bromo-9-benzyladenine (910 mg, 3.0 mmol), sodium hydrosulfide (1.08 g), and ethanol (50 ml) was refluxed for 12 h. After removal of solvent, the residue was dissolved into water and neutralized by 1 N HCl to obtain the desired compound as crystals (770 mg, Yield: 99%).

Workup

  1. temperaturewas refluxed for 12 h
  2. customAfter removal of solvent
  3. dissolutionthe residue was dissolved into water

Sources & evidence

ORD record
ord-e5c58f9a80d74a1c9b82a77493f265a4
Source dataset
uspto-grants-2000_02
Patent number
US06028076

Reaction notes

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