Thionyl Chloride → HCID 19356146, compound

HRID 377599Notes

Reaction equation

HRID 377599 reaction equation
[CH3:1][N:2]1[CH2:11][CH:10]([C:12]2[CH:13]=[C:14]([CH2:18][C:19]([OH:21])=O)[CH:15]=[CH:16][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.S(Cl)([Cl:24])=O>>[CH3:1][N:2]1[CH2:11][CH:10]([C:12]2[CH:13]=[C:14]([CH2:18][C:19]([Cl:24])=[O:21])[CH:15]=[CH:16][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 19356189HCID 19356189, compound

Product 1

HCID 19356146HCID 19356146, compound

Procedure

3.4 g (10.7 mmol) of 3-[2-methyl-1,2,3,4-tetrahydro-4-(R,S)-isoquinolinyl]phenylacetic acid are treated with 17.6 ml of thionyl chloride with stirring. The mixture is refluxed for one hour. The mixture is then evaporated to dryness. 3-[2-Methyl-1,2,3,4-tetrahydro-4-(R,S)-isoquinolinyl]phenylacetyl chloride is obtained.

Workup

  1. temperatureThe mixture is refluxed for one hour
  2. customThe mixture is then evaporated to dryness

Sources & evidence

ORD record
ord-4e5f5af84a1d4c0eb056ec1713b06ca0
Source dataset
uspto-grants-2000_02
Patent number
US06028080

Reaction notes

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