反应详情

1-Methylbarbituric acid (10 g) was suspended in phosphorus oxychloride (70 ml). Water (2 ml) was added and the mixture was heated at reflux for 40 minutes. The reaction was allowed to cool and was then concentrated under reduced pressure. The residue was poured onto a mixture of ice and water (200 ml). When the ice had melted, the precipitated solid was collected, washed with water and dried in vacuo at 50° C. to give the sub-title compound (6.86 g) as a yellow solid.

1. temperaturethe mixture was heated
2. temperatureat reflux for 40 minutes
3. temperatureto cool
4. concentrationwas then concentrated under reduced pressure
5. additionThe residue was poured onto a mixture of ice and water (200 ml)
6. customthe precipitated solid was collected
7. washwashed with water
8. customdried in vacuo at 50° C.