Water → HCID 19356079, compound

HRID 377614Notes

Reaction equation

HRID 377614 reaction equation
Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:19][N:20]1[C:25](=[O:26])[C:24]2=[CH:27][NH:28][N:29]=[C:23]2[N:22]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:21]1=[O:34].O>CC(C)=O>[CH3:19][N:20]1[C:25](=[O:26])[C:24]2=[CH:27][N:28]([CH2:2][C:3]3[C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[CH:6]=[CH:5][CH:4]=3)[N:29]=[C:23]2[N:22]([CH2:30][CH:31]([CH3:32])[CH3:33])[C:21]1=[O:34]

Participants

6

Reactant 4

HCID 962WaterHCID 68451-ChloromethylnaphthaleneHCID 11430Potassium CarbonateHCID 178448721HCID 178448721, compound

Product 1

HCID 19356079HCID 19356079, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In accordance with the teaching of German Patent No. 63,381, 1-(chloromethyl)-naphthalene (2.2 g), potassium carbonate (1.6 g) and 5-methyl-7-(2-methylpropyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (2.5 g) were combined in acetone (40 ml) and heated under reflux for 3 hours and then cooled to ambient temperature. Water (200 ml) was added and the precipitated solid was collected by filtration. The solid was triturated with isohexane and then dried in vacuo to give the title compound (3.64 g).

Workup

  1. temperatureheated
  2. temperatureunder reflux for 3 hours
  3. filtrationthe precipitated solid was collected by filtration
  4. customThe solid was triturated with isohexane
  5. customdried in vacuo

Sources & evidence

ORD record
ord-d390f58dd53e42ef875e29e53cfefd5a
Source dataset
uspto-grants-2000_02
Patent number
US06028074

Reaction notes

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