反应详情

温度

-72 °C

To a stirred solution of 3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole (7.2 g) in tetrahydrofuran (80 ml) at -78° C. under an atmosphere of nitrogen was added, at such a rate that the temperature of the reaction mixture did not exceed -71° C., n-butyllithium (8 ml of a 2.5M solution in hexanes). A solution of methyl propionate (3.2 ml) in tetrahydrofuran (10 ml) was then added at such a rate that the temperature of the reaction mixture did not exceed -72° C. Upon completion of the addition the mixture was stirred at -72° C. and then allowed to warm to room temperature over a period of 1.5 hours. After stirring overnight at room temperature water (100 ml) was added and the mixture extracted twice with ethyl acetate (200 ml). The combined organic layers were dried (Na2SO4) and evaporated to give a brown gum which was purified by column chromatography on silica gel (500 g) eluted with dichloromethane. Combination and evaporation of suitable fractions gave a brown solid which was further purified by column chromatography on silica gel (60 g) eluted with dichloromethane. Combination and evaporation of suitable fractions gave the title compound as a pale yellow solid, m.p. 143° C.

1. customdid not exceed -71° C.
2. customdid not exceed -72° C
3. additionUpon completion of the addition the mixture
4. temperatureto warm to room temperature over a period of 1.5 hours
5. additionwas added
6. extractionthe mixture extracted twice with ethyl acetate (200 ml)
7. dry with materialThe combined organic layers were dried (Na2SO4)
8. customevaporated
9. customto give a brown gum which
10. customwas purified by column chromatography on silica gel (500 g)
11. washeluted with dichloromethane
12. customCombination and evaporation of suitable fractions
13. customgave a brown solid which
14. customwas further purified by column chromatography on silica gel (60 g)
15. washeluted with dichloromethane
16. customCombination and evaporation of suitable fractions