Lithium borohydride → HCID 70288011, compound

HRID 377747Notes

Reaction equation

HRID 377747 reaction equation
[BH4-].[Li+].[CH3:3][S:4][C:5]1[CH:28]=[CH:27][C:8](/[CH:9]=[C:10]2/[C:11]([CH3:26])=[C:12]([CH2:22][C:23](Cl)=[O:24])[C:13]3[C:18]/2=[CH:17][CH:16]=[C:15]([N:19]([CH3:21])[CH3:20])[CH:14]=3)=[CH:7][CH:6]=1>C1COCC1>[CH3:3][S:4][C:5]1[CH:6]=[CH:7][C:8](/[CH:9]=[C:10]2/[C:11]([CH3:26])=[C:12]([CH2:22][CH2:23][OH:24])[C:13]3[C:18]/2=[CH:17][CH:16]=[C:15]([N:19]([CH3:20])[CH3:21])[CH:14]=3)=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 4148881Lithium borohydrideHCID 86755157HCID 86755157, compound

Product 1

HCID 70288011HCID 70288011, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Lithium borohydride (1.38 mmol) in THF (2 ml) is added to the suspension of (Z)-1-(4-methylthiobenzylidene)-5-dimethylamino-2-methyl-3-indenylacetyl chloride (2.78 mmol) in THF (20 ml) at 0° C. The reaction is quenched after 5 minutes with HCl (10%, aqueous, 30 ml). Ethyl acetate (50 ml) is added to extract the product.

Workup

  1. customThe reaction is quenched after 5 minutes with HCl (10%, aqueous, 30 ml)
  2. additionEthyl acetate (50 ml) is added
  3. extractionto extract the product

Sources & evidence

ORD record
ord-b24081a05f134c1da2b11ea2e38c81fd
Source dataset
uspto-grants-2000_02
Patent number
US06028116

Reaction notes

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