Lithium borohydride → HCID 70288212, compound

HRID 377749Notes

Reaction equation

HRID 377749 reaction equation
[BH4-].[Li+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)/[C:10](=[CH:14]\[C:15]1[CH:20]=[CH:19][C:18]([S:21][CH3:22])=[CH:17][CH:16]=1)/[C:9]([CH3:23])=[C:8]2[CH2:24][C:25](Cl)=[O:26]>C1COCC1>[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)/[C:10](=[CH:14]\[C:15]1[CH:16]=[CH:17][C:18]([S:21][CH3:22])=[CH:19][CH:20]=1)/[C:9]([CH3:23])=[C:8]2[CH2:24][CH2:25][OH:26]

Participants

4

Reactant 2

HCID 4148881Lithium borohydrideHCID 86755158HCID 86755158, compound

Product 1

HCID 70288212HCID 70288212, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Lithium borohydride (1.38 mmol) in THF (2 ml) is added slowly to a solution of (Z)-5-methoxy-2-methyl-1-(4-methylthiobenzylidene)-3-indenylacetyl chloride (2.78 mmol) in THF (20 ml) at 0° C. The reaction is quenched after 5 minutes with HCl (10%, aqueous, 30 ml). Ethyl acetate (50 ml) is added to extract the product.

Workup

  1. customThe reaction is quenched after 5 minutes with HCl (10%, aqueous, 30 ml)
  2. additionEthyl acetate (50 ml) is added
  3. extractionto extract the product

Sources & evidence

ORD record
ord-ad460c97ab354c0e82ac7e326e46a516
Source dataset
uspto-grants-2000_02
Patent number
US06028116

Reaction notes

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