HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → (Z)-5-Methoxy-2-methyl-1-(4-methylsulfonylbenzylidene)-3-indenylacetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (Z)-5-methoxy-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenylacetic acid | HCID 70286603 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (Z)-5-Methoxy-2-methyl-1-(4-methylsulfonylbenzylidene)-3-indenylacetyl chloride | HCID 86755164 | — |
Reaction Steps
(Z)-5-methoxy-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 35 ml) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06028116 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-f3ec563f032d4b35836b0afa092cb643 |
| Source note | uspto-grants-2000_02 |