Oxalyl chloride → (Z)-5-Methoxy-2-methyl-1-(4-methylsulfonylbenzylidene)-3-indenylacetyl chloride

HRID 377762ノート

反応式

HRID 377762 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)/[C:8](=[CH:12]\[C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1)/[C:7]([CH3:23])=[C:6]2[CH2:24][C:25]([OH:27])=O.C(Cl)(=O)C([Cl:31])=O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)/[C:8](=[CH:12]\[C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1)/[C:7]([CH3:23])=[C:6]2[CH2:24][C:25]([Cl:31])=[O:27]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 70286603(Z)-5-methoxy-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenylacetic acid

生成物 1

HCID 86755164(Z)-5-Methoxy-2-methyl-1-(4-methylsulfonylbenzylidene)-3-indenylacetyl chloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(Z)-5-methoxy-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 35 ml) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.

後処理

  1. customThe solvent is evaporated

出典と根拠

ORDレコード
ord-f3ec563f032d4b35836b0afa092cb643
出典データセット
uspto-grants-2000_02
特許番号
US06028116

反応ノート

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