HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pentylamine → HCID 19357217, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pentylamine | HCID 8060 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 4-[(5-Formylimidazol-1-yl)methyl]benzonitrile | HCID 10632289 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 19357217 | HCID 19357217 | — |
Reaction Steps
To a solution of the aldehyde 6 (132 mg) in 3 mL of 1,2-dichloroethane at 0° C. was added 4Å powdered molecular sieves (300 mg), n-pentylamine (0.217 mL), and sodium triacetoxyborohydride (260 mg). After five days, the reaction was poured into EtOAc and washed with water, sat. aq. NaHCO3 and brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the amine 7 as a brown oil which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06028201 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-081f8f3f87a24ef0b7b0b74460e93938 |
| Source note | uspto-grants-2000_02 |