反应详情

1-[(2-Methoxyquinolin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazine(106 mg, 0.25 mmol) was dissolved in dimethylfonnamide(15 ml) and sodium hydride(6.0 mg, 0.25 mmol) was added and the solution was stirred at room temperature for 15 min. Iodomethane(35 mg, 0.25 mmol) was added to the above solution. The mixture was stirred at room temperature for 16 hours and concentrated under the reduced pressure to remove dimethylformamide. The concentrate was purified by column chromatography(ethylacetate:hexane=1:2) to obtain the titled compound.

1. additionwas added
2. stirringThe mixture was stirred at room temperature for 16 hours
3. concentrationconcentrated under the reduced pressure
4. customto remove dimethylformamide
5. customThe concentrate was purified by column chromatography(ethylacetate:hexane=1:2)