1-(3,5-Difluorophenyl)piperazine → 1-[(2-Methylquinolin-3-yl)aminothiocarbonyl]-4-(3,5-difluorophenyl)piperazine

HRID 377903Notes

Reaction equation

HRID 377903 reaction equation
[CH3:1][C:2]1[C:11]([NH:12][C:13](=[S:21])OC2C=CC=CC=2)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:22][C:23]1[CH:24]=[C:25]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:26]=[C:27]([F:29])[CH:28]=1>>[CH3:1][C:2]1[C:11]([NH:12][C:13]([N:33]2[CH2:32][CH2:31][N:30]([C:25]3[CH:24]=[C:23]([F:22])[CH:28]=[C:27]([F:29])[CH:26]=3)[CH2:35][CH2:34]2)=[S:21])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 109872191-(3,5-Difluorophenyl)piperazineHCID 53717370Phenyl N-(2-methylquinolin-3-yl)thiocarbamate

Product 1

HCID 867551701-[(2-Methylquinolin-3-yl)aminothiocarbonyl]-4-(3,5-difluorophenyl)piperazineYield 74%

Procedure

Phenyl N-(2-methylquinolin-3-yl)thiocarbamate and 1-(3,5-difluorophenyl)piperazine were reacted by the same way with the example 125 to obtain the titled compound.

Sources & evidence

ORD record
ord-b169f8dbf78b4c87bded5e0ba1d18f78
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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