反应详情

To 3,4-dimethylphenol(12.1 g, 0.1 mol), trifluoroacetic acid(250 ml) was added, and in water bath sodium nitrite(12.4 g, 0.18 mol) was added slowly. The resulting mixture was stirred at room temperature for 14 hours and concentrated under the reduced pressure to remove trifluoroacetic acid, followed by addition of water(150 ml), extracted with ether and purified by column chromatography to obtain the titled compound.

1. concentrationconcentrated under the reduced pressure
2. customto remove trifluoroacetic acid
3. additionfollowed by addition of water(150 ml)
4. extractionextracted with ether
5. custompurified by column chromatography