Ethylamine → HCID 18630106, compound

HRID 378020Notes

Reaction equation

HRID 378020 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Si:8]([CH3:11])([CH3:10])[CH3:9])[C:3]=1[N:12]=[C:13]=[O:14].[CH2:15]([NH2:17])[CH3:16].C(OCC)(=O)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Si:8]([CH3:10])([CH3:11])[CH3:9])[C:3]=1[NH:12][C:13]([NH:17][CH2:15][CH3:16])=[O:14]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 8857Ethyl AcetateHCID 18630278HCID 18630278, compound

Product 1

HCID 18630106HCID 18630106, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of the compound of Example h (4 mmol) in 50 mL toluene was added 70% ethyl amine (4 mL). The solution was stirred for 0.5 h and then stood overnight. Ethyl acetate was added and the mixture was washed with water. The organic layer was concentrated to a semisolid, which was triturated with hexane. The title compound was collected by filtration as 0.9 g of crystals, an 83% yield. m.p. 161-163° C.

Workup

  1. waitstood overnight
  2. washthe mixture was washed with water
  3. concentrationThe organic layer was concentrated to a semisolid, which
  4. customwas triturated with hexane
  5. filtrationThe title compound was collected by filtration as 0.9 g of crystals

Sources & evidence

ORD record
ord-67ba3f7e6f3c441c890bc507a24717e4
Source dataset
uspto-grants-2000_02
Patent number
US06028101

Reaction notes

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