反应详情

In a 250 mL flask equipped with a Dean-Start separator, the following mixture is brought to reflux: 9.3 g of aniline, 12.1 g 2-norbornanone, 13.2 g benzotriazole and 120 mL xylene. After 16 h, the mixture is reduced to dryness, then it is solubilized in 300 mL methanol, and the product is reduced with 6 g NaBH4 at 50° C. for 1 h. The mixture is then poured into 200 mL water and the organic product is extracted with 3×100 mL toluene. The organic phase is recovered, dried over magnesium sulfate, and then reduced to dryness. In this manner, 20 g of the desired amine are produced.

1. customIn a 250 mL flask equipped with a Dean-Start separator
2. temperatureto reflux
3. extractionthe organic product is extracted with 3×100 mL toluene
4. customThe organic phase is recovered
5. dry with materialdried over magnesium sulfate