反应详情

A solution of 1-methyl-piperidine-4-carboxylic acid ethyl ester (2.0 g, 11.7 mmol) in conc. hydrochloric acid (20 mL) was heated to 100° C. and maintained for 6 h. The mixture was then concentrated to dryness in vacuo to give a solid, which was washed with acetonitrile-diethyl ether (1:1) and dried in vacuo to afford 1-methyl-piperidine-4-carboxylic acid hydrochloride (1.0 g, 48%) as an off-white solid.

1. temperaturemaintained for 6 h
2. concentrationThe mixture was then concentrated to dryness in vacuo
3. customto give a solid, which
4. washwas washed with acetonitrile-diethyl ether (1:1)
5. customdried in vacuo