Methyl iodide → HCID 19353310, compound

HRID 378257Notes

Reaction equation

HRID 378257 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:8]3[CH2:9][NH:10][C:11](=[O:23])[C:12]=3[CH:13]=[C:14]3[CH:22]=[CH:21][C:20]4[O:19][CH2:18][O:17][C:16]=4[C:15]=23)=[CH:3][CH:2]=1.[CH3:24][I:25]>CO>[I-:25].[O:17]1[C:16]2[C:15]3[C:14]([CH:22]=[CH:21][C:20]=2[O:19][CH2:18]1)=[CH:13][C:12]1[C:11](=[O:23])[NH:10][CH2:9][C:8]=1[C:7]=3[C:4]1[CH:5]=[CH:6][N+:1]([CH3:24])=[CH:2][CH:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19353280HCID 19353280, compound

Product 1

HCID 19353310HCID 19353310, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol (10 ml) solution of 8,9-dihydro-10-(4-pyridyl)-7H-1,3-benzodioxolo[4,5-f]isoindol-7-one (63 mg) was added methyl iodide (3 ml) and heated under reflux for 3 hours. The resultant precipitates were collected by suction and recrystallized from methanol-THF to give the entitled compound (51 mg) as yellow crystals.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 3 hours
  3. customThe resultant precipitates
  4. customwere collected by suction
  5. customrecrystallized from methanol-THF

Sources & evidence

ORD record
ord-05cf7c17698f4b678ff2764540412f62
Source dataset
uspto-grants-2000_02
Patent number
US06030967

Reaction notes

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