Dichloromethane → HCID 86755177, compound

HRID 378258Notes

Reaction equation

HRID 378258 reaction equation
ClCCl.[N:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]3[CH2:12][NH:13][C:14](=[O:26])[C:15]=3[CH:16]=[C:17]3[CH:25]=[CH:24][C:23]4[O:22][CH2:21][O:20][C:19]=4[C:18]=23)=[CH:6][CH:5]=1.C1C=C(Cl)C=C(C(OO)=[O:35])C=1>O>[N:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]3[CH2:12][NH+:13]([O-:35])[C:14](=[O:26])[C:15]=3[CH:16]=[C:17]3[CH:25]=[CH:24][C:23]4[O:22][CH2:21][O:20][C:19]=4[C:18]=23)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 70297m-Chloroperbenzoic acidHCID 19353280HCID 19353280, compound

Product 1

HCID 86755177HCID 86755177, compoundYield 39.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a dichloromethane (100 ml) solution of 8,9-dihydro-10-(4-pyridyl)-7H-1,3-benzodioxolo[4,5-f]isoindol-7-one (200 mg) was added MCPBA (350 mg) and stirred for 2 hours at room temperature. To the reaction mixture was added water. The organic layer was taken and washed with sodium hydrogencarbonate solution and water. The mixture was dried with magnesium sulfate and concentrated to give the entitled compound (84 mg).

Workup

  1. washwashed with sodium hydrogencarbonate solution and water
  2. dry with materialThe mixture was dried with magnesium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-ef42da8a15f949f49bad4217a48177b6
Source dataset
uspto-grants-2000_02
Patent number
US06030967

Reaction notes

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