Hydrochloric Acid → HCID 17774541, compound

HRID 378273Notes

Reaction equation

HRID 378273 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[C:16]([NH:18][CH2:19][CH3:20])[N:15]=[C:14]([NH:21][CH2:22][CH3:23])[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:24]>CO>[ClH:24].[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[C:16]([NH:18][CH2:19][CH3:20])[N:15]=[C:14]([NH:21][CH2:22][CH3:23])[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10568877HCID 10568877, compound

Product 1

HCID 17774541HCID 17774541, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

0.79 g (0.00234 mol) of 4-amino-N-(2,6-bis-ethylamino-pyrimidin-4-yl)-benzenesulfonamide was dissolved in 150 ml of methanol, treated with 2.0 ml (0.0070 mol) of 3.5N ethanolic hydrochloric acid and stirred at 0° C. for 2 hours. The solution was freed completely from solvent and the residue was recrystallized from ethanol/diethyl ether. There was obtained 0.61 g (70%) of 4-amino-N-(2,6-bis-ethylamino-pyrimidin-4-yl)-benzenesulfonamide hydrochloride as pale beige crystals; m.p. 197-208° C.

Workup

  1. customthe residue was recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-9e9ed367477a4e21a733d5e67e27847c
Source dataset
uspto-grants-2000_02
Patent number
US06030976

Reaction notes

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