Hydrochloric Acid → HCID 17774526, compound

HRID 378276Notes

Reaction equation

HRID 378276 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[C:16]([NH:18][CH2:19][CH2:20][CH3:21])[N:15]=[C:14]([NH:22][CH2:23][CH2:24][CH3:25])[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:26]>CO>[ClH:26].[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[C:16]([NH:18][CH2:19][CH2:20][CH3:21])[N:15]=[C:14]([NH:22][CH2:23][CH2:24][CH3:25])[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 17774507HCID 17774507, compound

Product 1

HCID 17774526HCID 17774526, compoundYield 104.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

0.75 g (0.00205 mol) of 4-amino-N-(2,6-bis-propylamino-pyrimidin-4-yl)-benzenesulfonamide was dissolved in 100 ml of methanol, treated with 1.5 ml (0.0062 mol) of 3.5N ethanolic hydrochloric acid and stirred at 0° C. for 2 hours. The solution was freed completely from solvent and the residue was recrystallized from ethanol/diethyl ether. There was obtained 0.86 g (82%) of 4-amino-N-(2,6-bis-propylamino-pyrimidin-4-yl)-benzenesulfonamide hydrochloride as beige crystals; m.p. 189-195° C.

Workup

  1. customthe residue was recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-681a954fd82c41bc87798c9134694197
Source dataset
uspto-grants-2000_02
Patent number
US06030976

Reaction notes

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