Hydrochloric Acid → HCID 19353539, compound

HRID 378309Notes

Reaction equation

HRID 378309 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([NH:18]C(=O)C)=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:5]=[C:4]([CH3:22])[N:3]=1.Cl>[OH-].[Na+]>[NH2:18][C:15]1[CH:16]=[CH:17][C:12]([S:9]([NH:8][C:6]2[CH:5]=[C:4]([CH3:22])[N:3]=[C:2]([Br:1])[CH:7]=2)(=[O:11])=[O:10])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53949666HCID 53949666, compound

Product 1

HCID 19353539HCID 19353539, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

1.15 g (0.003 mol) of N-[4-(2-bromo-6-methyl-pyridin-4-ylsulfamoyl)-phenyl]-acetamide were dissolved in 15 ml of 2N NaOH and boiled at reflux for 1 hour. After cooling the mixture was acidified to pH 5 with 2N HCl and the colourless precipitate which separated was filtered off. The material on the suction filter was washed with copious water and dried. There was obtained 0.95 g (93%) of 4-amino-N-(2-bromo-6-methyl-pyridin-4-yl)-benzenesulfonamide as colorless crystals; m.p.: >110° C. (dec.).

Workup

  1. temperatureat reflux for 1 hour
  2. temperatureAfter cooling the mixture
  3. customthe colourless precipitate which separated
  4. filtrationwas filtered off
  5. filtrationThe material on the suction filter
  6. washwas washed with copious water
  7. customdried

Sources & evidence

ORD record
ord-0423dc1b5f5448b9ac61f7818c188626
Source dataset
uspto-grants-2000_02
Patent number
US06030976

Reaction notes

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