HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-2-nitroaniline → 2-Nitro-4-toluonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-2-nitroaniline | HCID 6978 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Catalyst | Copper Sulfate | HCID 24462 | — |
| Product | 2-Nitro-4-toluonitrile | HCID 96235 | — |
Reaction Steps
11.75 g (77.2 mmol) of 4-methyl-2-nitroaniline underwent a Sandmeyer reaction in a conventional process by diazotization and substitution with NaCN and CuSO4 to give 9.6 g of crude 4-methyl-2-nitrobenzonitrile. 1H-NMR (DMSO-d6, δ in ppm): 8.25 (1H), 8.05 (1H), 7.80 (1H), 2.50 (3H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06030972 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-1b522b4234d046afb932a038441e9a2f |
| Source note | uspto-grants-2000_02 |