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HRID378328

反应详情

EQUATION

反应方程式

HRID 378328 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(N)c([N+](=O)[O-])c1
HCID6978

4-Methyl-2-nitroaniline

C7H8N2O2

结构：[C-]#N.[Na+]
HCID8929

Sodium cyanide (Na(CN))

CNNa

PRODUCTS

生成物

1
结构：Cc1ccc(C#N)c([N+](=O)[O-])c1
HCID96235

2-Nitro-4-toluonitrile

C8H6N2O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=S(=O)([O-])[O-].[Cu+2]
催化剂HCID24462

Copper sulfate

CuO4S

PROCEDURE

实验过程

11.75 g (77.2 mmol) of 4-methyl-2-nitroaniline underwent a Sandmeyer reaction in a conventional process by diazotization and substitution with NaCN and CuSO4 to give 9.6 g of crude 4-methyl-2-nitrobenzonitrile. 1H-NMR (DMSO-d6, δ in ppm): 8.25 (1H), 8.05 (1H), 7.80 (1H), 2.50 (3H)