反应详情

A mixture of methyl 5-formyl-2-methoxybenzoate (490 mg), thiazolidine-2,4-dione (358 mg), ammonium acetate (401 mg), acetic acid (0.8 ml) and benzene (10 ml) was submitted to Dean-Stalk dewatering apparatus to reflux for 4 hours under heat. After cooling, the crystals deposited were collected by filtration, washed with benzene and with 20% aqueous solution of acetone, and then dried to obtain 634 mg (86%) of aimed compound as crystals.

1. temperatureto reflux for 4 hours
2. temperatureunder heat
3. temperatureAfter cooling
4. filtrationthe crystals deposited were collected by filtration
5. washwashed with benzene and with 20% aqueous solution of acetone
6. customdried