Hydrochloric Acid → HCID 178503517, compound

HRID 378357Notes

Reaction equation

HRID 378357 reaction equation
C[O:2][C:3]([CH:5]1[C:9](=O)[CH2:8][CH2:7][CH2:6]1)=O.S(O)(O)(=O)=O.[CH3:16][S:17][C:18](=[NH:20])[NH2:19].[OH-].[K+].Cl>CO.O>[CH3:16][S:17][C:18]1[N:20]=[C:3]([OH:2])[C:5]2[CH2:6][CH2:7][CH2:8][C:9]=2[N:19]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 66328Cyclopentanecarboxylic acid, 2-oxo-, methyl esterHCID 752702-Methyl-2-thiopseudourea sulfate

Product 1

HCID 178503517HCID 178503517, compoundYield 57.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

46.9 g (330 mmol) of methyl cyclopentanone-2-carboxylate and 53.5 g (192 mmol) of S-methylisothiourea sulfate were successively added to 29.6 g (528 mmol) of KOH in 396 ml of methanol, and the mixture was stirred at room temperature overnight, acidified with 1N hydrochloric acid and diluted with water. The crystals which separated out were filtered off with suction and dried. 20 g of crystals were obtained.

Workup

  1. customThe crystals which separated out
  2. filtrationwere filtered off with suction
  3. customdried

Sources & evidence

ORD record
ord-124e82f2d5bd4e998bc7d93dd02a8d10
Source dataset
uspto-grants-2000_02
Patent number
US06030975

Reaction notes

Loading…