Hydrogen Bromide → HCID 19354001, compound

HRID 378393Notes

Reaction equation

HRID 378393 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][CH:25]=1)[CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=1.[BrH:26]>C(O)(=O)C>[BrH:26].[OH:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][CH:25]=1)[CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 19353915HCID 19353915, compound

Product 1

HCID 19354001HCID 19354001, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

This compound was prepared by first synthesizing 1-(3-methoxybenzyl)-2-(3-methylphenyl)benzimidazole as described in Example 65, supra. With an amount of the compound of Example 65 (4.31 g, 13.12 mmol) in glacial acetic acid (50 ml) and hydrobromic acid (300 ml of a 48% w/v in acetic acid solution). This mixture was stirred for 2 hours while warming to reflux. The mixture was then stirred at reflux for about three hours.

Workup

  1. temperaturewhile warming to reflux
  2. stirringThe mixture was then stirred
  3. temperatureat reflux for about three hours

Sources & evidence

ORD record
ord-77ede48ee7f147538133696511c507a7
Source dataset
uspto-grants-2000_02
Patent number
US06030992

Reaction notes

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