Acetone → HCID 19354005, compound

HRID 378396Notes

Reaction equation

HRID 378396 reaction equation
[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14](O)[CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25](=[O:28])([O-])[O-].[K+].[K+].[CH3:31][C:32]([CH3:34])=O>>[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([O:28][CH2:25][CH2:9][N:8]3[CH2:1][CH2:2][CH2:34][CH2:32][CH2:31]3)[CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 19354025HCID 19354025, compound

Product 1

HCID 19354005HCID 19354005, compound

Procedure

The title compound was synthesized by reacting the compound of Example 84, supra, (0.25 g, 0.79 mmol) with 2-(piperdinyl-1-yl)ethyl chloride (17.46 g, 7.9 mmol) in the presence of potassium carbonate (2.20 g, 15.9 mmol) and acetone (150 ml). These contents were added to a flask and refluxed overnight.

Workup

  1. additionThese contents were added to a flask
  2. temperaturerefluxed overnight

Sources & evidence

ORD record
ord-32fba917d02749f8a7257f277d2a2e5d
Source dataset
uspto-grants-2000_02
Patent number
US06030992

Reaction notes

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