Morpholine → HCID 15388686, compound

HRID 378397Notes

Reaction equation

HRID 378397 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]([N:14]1[C:18]2[CH:19]=[C:20]([O:23][CH2:24][CH2:25][CH2:26]Cl)[CH:21]=[CH:22][C:17]=2[N:16]=[C:15]1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH3:34])[CH:29]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(C1C=CC=CC=1N(C(C)C)CC)(C)C>C(#N)C>[CH2:7]([N:14]1[C:18]2[CH:19]=[C:20]([O:23][CH2:24][CH2:25][CH2:26][N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)[CH:21]=[CH:22][C:17]=2[N:16]=[C:15]1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH3:34])[CH:29]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 19353966HCID 19353966, compoundHCID 50937077HCID 50937077, compound

Product 1

HCID 15388686HCID 15388686, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared by first adding morpholine (1.02 g, 11.77 mmol) and the compound of Example 97, supra, (0.39 g, 1.00 mmol) to 125 ml of acetonitrile while stirring under nitrogen purge. To this mixture is then added diisopropylethyl aniline (1.51 ml, 8.67 mmol) dropwise. This reaction mixture is then allowed to stir overnight.

Workup

  1. custompurge

Sources & evidence

ORD record
ord-520e454afca0463e89bedb29367d56ea
Source dataset
uspto-grants-2000_02
Patent number
US06030992

Reaction notes

Loading…