(1,1'-Biphenyl)-4-sulphonyl chloride → N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide

HRID 378426Notes

Reaction equation

HRID 378426 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH3:11].[C:12]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>>[CH3:11][C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:18]([C:15]1[CH:14]=[CH:13][C:12]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:17][CH:16]=1)(=[O:20])=[O:19]

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 156138784-Methyl-3-(trifluoromethyl)isoxazol-5-amine

Product 1

HCID 15453174N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamideYield 78%

Procedure

N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide was prepared, as described in Example 2, from 5-amino-4-methyl-3-trifluoromethylisoxazole and 4-biphenylsulfonyl chloride in 78% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a white solid, m.p. 139-140° C.

Workup

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a white solid, m.p. 139-140° C.

Sources & evidence

ORD record
ord-55c1df40252746789d3d930b48592961
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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