HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1,1'-Biphenyl)-4-sulphonyl chloride → N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1,1'-Biphenyl)-4-sulphonyl chloride | HCID 74192 | — |
| Reactant | 4-Methyl-3-(trifluoromethyl)isoxazol-5-amine | HCID 15613878 | — |
| Product | N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide | HCID 15453174 | 78% |
Reaction Steps
N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide was prepared, as described in Example 2, from 5-amino-4-methyl-3-trifluoromethylisoxazole and 4-biphenylsulfonyl chloride in 78% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a white solid, m.p. 139-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06030991 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-55c1df40252746789d3d930b48592961 |
| Source note | uspto-grants-2000_02 |