2-Phenylbenzene-1-sulfonyl chloride → N-(4-bromo-3-methyl-5-isoxazolyl)-2-biphenylsulfonamide

HRID 378431Notes

Reaction equation

HRID 378431 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[C:9]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:10]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:12]=[CH:13][CH:14]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:15]([C:10]1[C:9]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:17])=[O:16]

Participants

3

Reactant 2

HCID 27566802-Phenylbenzene-1-sulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 15453177N-(4-bromo-3-methyl-5-isoxazolyl)-2-biphenylsulfonamideYield 71%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-2-biphenylsulfonamide was prepared in the same manner as described in Example 8b from 5-amino-4-bromo-3-methylisoxazole and 2-biphenylsulfonyl chloride in 71% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 145-147° C.

Workup

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 145-147° C.

Sources & evidence

ORD record
ord-5132a8aa5278454ba9c6fb83b96ede67
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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