反应详情

A mixture of 1-phenyl-piperidin-4-one (180 mg, 1.03 mmol) and hydroxylamine hydrochloride (142 mg, 2.06 mmol) in methanol (10 mL) was heated at reflux for 6 h. The solvent was evaporated and the residue diluted with water. The mixture was extracted with ethyl acetate then the organic phase was washed with water, brine, dried over anhydrous sodium sulfate and concentrated to afford 1-phenyl-piperidin-4-one oxime (0.18 g, 92%) as a liquid.

1. temperaturewas heated
2. temperatureat reflux for 6 h
3. customThe solvent was evaporated
4. additionthe residue diluted with water
5. extractionThe mixture was extracted with ethyl acetate
6. washthe organic phase was washed with water, brine
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated