反应详情

A mixture of 4'-hydroxy-3'-methylacetophenone (5.0 g, 33.3 mmol), iodomethane (5.7 g, 40.0 mmol), K2CO3 (granular, anhydrous) (23.0 g, 167 mmol), and acetone (250 mL) was refluxed for 3 hours. The reaction mixture was then cooled to room temperature, filtered to remove the inorganic salts, and evaporated under vacuum. The crude product was dissolved in ether (100 mL) and washed with H2O (2×20 mL). The organic layer was dried (Na2SO4) and evaporated to yield 4.5 g, 82.4% yield. The ketone was used in the following reaction without further purification.

1. temperaturewas refluxed for 3 hours
2. filtrationfiltered
3. customto remove the inorganic salts
4. customevaporated under vacuum
5. dissolutionThe crude product was dissolved in ether (100 mL)
6. washwashed with H2O (2×20 mL)
7. dry with materialThe organic layer was dried (Na2SO4)
8. customevaporated
9. customto yield 4.5 g, 82.4% yield