反应详情

In 15 ml of trifluoroacetic acid was dissolved 1.76 g of Compound (44). After 1 hour, the solution was concentrated under reduced pressure. To the residue was added 100 ml of water, and the mixture was washed with benzene. The aqueous layer was adjusted to a pH of 12 with sodium hydroxide and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated to obtain the titled compound (45) as a colorless oil.

1. concentrationthe solution was concentrated under reduced pressure
2. additionTo the residue was added 100 ml of water
3. washthe mixture was washed with benzene
4. extractionextracted with chloroform
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. customthe solvent was evaporated